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In 1998, approved by the FDA, how Viagra is a medicine for the safe and effective treatment for erectile dysfunction. Sildenafil Citrate is the active ingredient of Viagra – a PDE-5 inhibitor of the drug increases the blood flow, the penis to increase speed. It is recommended to take generic Sildenafil online pills, close medical supervision in order to avoid some of the light-moderate side effects. But in the last few years, there were reports of recreational use of Sildenafil. Man has never suffered from erectile dysfunction when you use generic Sildenafil online pills only improve endurance.

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Sildenafil citrate medication is produced by various pharmaceutical companies all over the world. Many of these companies sell Sildenafil citrate under original trade names. However, there are such manufacturers that sell this medication for erectile dysfunction treatment under international non-proprietary name Sildenafil (or Sildenafil citrate).

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Although, we all know the power of Sildenafil Citrate tablets online in the treatment of erectile dysfunction in men, we are not aware of the details of how it works. Sildenafil Citrate tablets online really should be the medicine helps to how men and women get rid of impotence, but he also got very much for it, only to renew, if their sexual relations. There is nothing wrong and Pfizer assured that order Sildenafil Citrate tablets online packs and everything else, to make their sex life, the better. However, before I get Sildenafil Citrate tablets online to have in mind some points. I have listed below 5 points deserve consideration.

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Sildenafil Dosage

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Tablets, capsules or jelly containing Sildenafil citrate are for oral administration only. Frequency of Sildenafil citrate use must not exceed one dose a day. An optimal Sildenafil citrate daily dose depends on the severity of erectile dysfunction, man’s age, as well as some comorbidities or their absence.

When should I take Sildenafil citrate?

  • Quick-release forms of Sildenafil citrate (oral jelly, chewable tablets) help to recover erection within just 10-15 minutes after oral intake.
  • Film-coated tablets or extended-release capsules Sildenafil citrate provide restoration of erection within approximately 30 minutes after oral use.
  • If Sildenafil citrate is taken along with other drugs, or after man had some fatty food, erection may be restored with 1-hour delay.

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Clinical trials results have proven that Sildenafil citrate causes mild to moderate side effects in most men. Thus, about 2.5% of all men, who were taking Sildenafil citrate during the trials, had to stop ED drug therapy because of severe side effects.

  • The most common Sildenafil citrate side effects are headache, dyspepsia or flushing.
  • Rarely, Sildenafil citrate side effects appear as nasal congestion, diarrhea or abnormal vision.
  • Some men, taking Sildenafil citrate are at high risk of urinary tract infection, dizziness or rash.
  • In single cases, Sildenafil citrate causes back pain, arthralgia, flu syndrome or respiratory tract infection.

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Sildenafil Citrate Drug Interactions

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Clinical studies results have demonstrated that Sildenafil citrate may interact with other drugs. For instance, specific CYP inhibitors, nonspecific CYP inhibitors and P450 inhibitors can increase the concentration of Sildenafil citrate in the blood plasma.

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  •     Nonspecific CYP inhibitor Cimetidine can increase the concentration of Sildenafil citrate by more than 50% in the blood plasma.
  •     Specific CYP inhibitor Saquinavir can increase the concentration of Sildenafil citrate by approximately 140% in the blood plasma.
  •     Specific CYP inhibitor Erythromycin can increase the concentration of Sildenafil citrate by over 180% in the blood plasma.
  •     Powerful P450 inhibitor Ritonavir can increase the concentration of Sildenafil citrate by almost 300% in the blood plasma.

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Sildenafil Citrate and General Precautions

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Many mature and elderly men have erectile dysfunction (ED), associated with hypertension. For hypertension treatment, alpha blockers (e.g.: Prazosin, Doxazosin, Terazosin, Phenoxybenzamine) are prescribed for men.

Given the fact that Sildenafil citrate can increase hypotensive effect of alpha blockers, men may suffer dizziness and even fainting after the joint use of these drugs.

  • If unstable hemodynamics is observed in men after the use of alpha blockers alone, he should start the ED treatment with minimal doses of Sildenafil citrate.
  • If man is already taking Sildenafil citrate but has never taken alpha blockers, he should start anti-hypertension therapy with minimal doses of alpha blockers.

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Sildenafil Citrate Contraindications

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Sildenafil citrate can increase hypotensive effect of organic nitrates (for example, nitroglycerin). Even if organic nitrates are taken irregularly, a sharp drop of blood pressure may happen after the use of Sildenafil citrate.

To prevent a strong hypotensive effect, men taking organic nitrates, should refrain from using Sildenafil citrate.

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Indications For the Use of Sildenafil Citrate

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Sildenafil citrate is prescribed for young men older than 18 years, adult men and elderly men for treatment of:

  • Psychogenic erectile dysfunction
  • Organic erectile dysfunction
  • Mixed erectile dysfunction

Sildenafil citrate is prescribed even in those cases when men may have erection, yet he is unhappy with its quality or duration.

Sildenafil citrate neither affects the CNS, nor causes drug dependence and severe side effects. Therefore, Sildenafil citrate tablets (capsules, oral jelly) can be used in a long-term therapy of ED regardless of the men’s age and the cause of deterioration of erectile dysfunction.

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The Results of Clinical Trials of Sildenafil Citrate

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Clinical trials of Sildenafil citrate included over 3000 men aged 19 to 87 (inclusive). Each of these men was diagnosed psychogenic, organic or mixed erectile dysfunction (ED).

  • In total, 21 of trials were conducted, lasting up to 6 months.
  • An average duration of ED in men, who took part in the trials of Sildenafil citrate, was 5 years.

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