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Pharmacodynamic Parameters of Sildenafil

Biil Jonh 0 Comments

The basic Sildenafil citrate metabolite is N-desmethyl. The fact is that N-desmethyl metabolite circulates in the blood plasma, just as Sildenafil citrate does. About 20% of pharmacological effect of Sildenafil citrate is provided namely by N-desmethyl metabolite.

After oral intake, Sildenafil citrate is excreted from the body in form of active and inactive metabolites.

  • About 80% of the dose of Sildenafil citrate is excreted with feces.
  • About 13% of Sildenafil citrate dose is excreted with urine.

It must be said that the excretion rate of Sildenafil citrate (and its metabolites) from the body decreases in elderly men over 65 years old with hepatic disorders and severe kidney disease. Hence, this group of patients might need an individual dose adjustment of Sildenafil citrate.

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Sildenafil Citrate – Mechanism of Action

Biil Jonh 0 Comments
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Sildenafil citrate is an active ingredient, used in production of oral medications for treatment of erectile dysfunction. On international pharmaceutical market, you may find:

  •     Oral tablets, containing Sildenafil citral
  •     Oral capsules, containing Sildenafil citrat
  •     Chewable tablets, containing Sildenafil citrate
  •     Oral jelly, containing Sildenafil citrate

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