The Results of Clinical Trials of Sildenafil Citrate

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Clinical trials of Sildenafil citrate included over 3000 men aged 19 to 87 (inclusive). Each of these men was diagnosed psychogenic, organic or mixed erectile dysfunction (ED).

  • In total, 21 of trials were conducted, lasting up to 6 months.
  • An average duration of ED in men, who took part in the trials of Sildenafil citrate, was 5 years.

 

These clinical trials were aimed at establishing the influence of therapeutic doses of Sildenafil citrate 25mg, 50mg and 100mg on sexual activity of men with ED. The results of each of these 21 trials have shown that Sildenafil citrate reliably helps to:

  • Achieve erection, sufficient for intravaginal penetration
  • Save erection, sufficient for satisfactory sexual activity

 

Thanks to different assessment instruments (e.g. IIEF), used to study the efficiency of Sildenafil citrate, it has been found that:

  • Even the minimal dose Sildenafil citrate 25mg can restore male sexual function.
  • Erectile function can be maximally improved by increasing the dose of Sildenafil citrate up to 50mg or 100mg.

Four (of 21) clinical trials, lasting 3 to 6 months, involved 1797 men with ED. During these clinical trials:

  • 64% of men have reported that their sexual function has improved with minimal dose Sildenafil citrate 25mg.
  • 74% of men have reported about improved sexual function in response to medium dose Sildenafil citrate 50mg.
  • 82% of men have reported about the improvement of their sexual function after the use of maximal dose Sildenafil citrate 100mg.

Moreover, Sildenafil citrate not only restores the erectile function, but also improves many other aspects of sexual life. Such as:

  • Sexual desire
  • Frequency and duration of orgasm
  • Sexual satisfaction

 

Sildenafil citrate and diabetes

One of the clinical trials of Sildenafil citrate included men, who suffered from ED and diabetes. The results of these trials have shown that diabetic men should take an average dose Sildenafil citrate 50mg or a maximal dose Sildenafil citrate 100mg to improve their erectile function significantly. If ED is associated with diabetes, a minimal dose Sildenafil citrate 25mg does not provide the anticipated recovery of the sexual function.

Sildenafil citrate and prostatitis

No less important fact is that Sildenafil citrate helps to get erection even after the transurethral resection of the prostate and radical prostatectomy. However, one must know that chances are 1:2 to improve erection by means of Sildenafil citrate after radical prostatectomy.

Conclusion

Monitoring of men’s behavior while they have been using Sildenafil citrate, have demonstrated that this drug for erectile dysfunction treatment helps to restore the erection and improves the quality of sexual life, regardless of:

  • The ED causes
  • Severity of ED
  • Race and ethnicity
  • Men’s age

Another important fact is that Sildenafil citrate helps to achieve erection if ED is complicated by: cardiovascular diseases, hypertension, depression, diabetes, prostatic and (or) spinal cord diseases.

Herewith, Sildenafil citrate provides erection improvement even if man takes drugs for the treatment of depression and (or) neuroleptics, diuretics and (or) antihypertensive drugs.

Some drugs can affect the safety and efficacy of Sildenafil citrate. Therefore, one should learn more information on Sildenafil citrate drug interactions before including it into combination drug therapy.

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