Sildenafil Citrate Drug Interactions

Clinical studies results have demonstrated that Sildenafil citrate may interact with other drugs. For instance, specific CYP inhibitors, nonspecific CYP inhibitors and P450 inhibitors can increase the concentration of Sildenafil citrate in the blood plasma.

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  •     Nonspecific CYP inhibitor Cimetidine can increase the concentration of Sildenafil citrate by more than 50% in the blood plasma.
  •     Specific CYP inhibitor Saquinavir can increase the concentration of Sildenafil citrate by approximately 140% in the blood plasma.
  •     Specific CYP inhibitor Erythromycin can increase the concentration of Sildenafil citrate by over 180% in the blood plasma.
  •     Powerful P450 inhibitor Ritonavir can increase the concentration of Sildenafil citrate by almost 300% in the blood plasma.

  •     Nonspecific CYP inhibitor Cimetidine can increase the concentration of Sildenafil citrate by more than 50% in the blood plasma.
  •     Specific CYP inhibitor Saquinavir can increase the concentration of Sildenafil citrate by approximately 140% in the blood plasma.
  •     Specific CYP inhibitor Erythromycin can increase the concentration of Sildenafil citrate by over 180% in the blood plasma.
  •     Powerful P450 inhibitor Ritonavir can increase the concentration of Sildenafil citrate by almost 300% in the blood plasma.

Increased concentration of Sildenafil citrate in the blood plasma may cause side effects. Therefore, when men are prescribed P450 inhibitors or CYP inhibitors, it is recommended to change the dose regimen for Sildenafil citrate.

Some drugs do not increase, but decrease Sildenafil citrate concentration in the blood plasma.

For example, CYP3A4 inducers Bosentan and Rifampin may reduce the concentration of Sildenafil citrate in the plasma by more than 50%. Thus, men taking Sildenafil citrate along with Rifampin, Bosentan or other CYP3A4 inducers, may face some problems with erection.

It must be said that hundreds of different drugs do not violate the efficacy and safety of Sildenafil citrate. Therefore, most men can undergo a drug ED treatment along with drug therapy of other diseases.

According to results of clinical studies, Sildenafil citrate efficiency is not affected by the following drug groups: SSRIs, tricyclic antidepressants, calcium channel blockers, ACE inhibitors, thiazide diuretics, hypoglycemic drugs and anticoagulants (including Aspirin).

Still, one must remember that other drugs can affect the efficiency and safety of Sildenafil citrate, since Sildenafil citrate influences the therapeutic properties of other drugs. For instance, Sildenafil citrate can:

  • Increase the antiaggregatory effect of drugs containing Sodium Nitroprusside
  • Increase hypotensive effect of drugs containing Doxazosin mesylate or Amlodipine

If you decide to order Sildenafil citrate online, yet have never ordered the shipping of drugs for ED treatment on online pharmacies, please ask your questions by phone or email.

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